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Laurie Metcalf is best known for her role as Roseanne Barr 's sister "Jackie" on the hit series Roseanne , but she wasn't always living in the enormous shadow of the comic behemoth. In fact, Laurie started acting in the Steppenwolf Theater in Chicago alongside other such notables as John Malkovich , Glenne Headly , and Gary Sinese , all of whom she has worked with in cinema. Although her offbeat looks generally land her in supporting roles, Laurie tends to steal the show, as she did with Malkovich in Making Mr. Right and in the John Candy comedy Uncle Buck She got her start with a one-season stint on Saturday Night Live in but quickly moved on to bigger and better things, next appearing in Desperately Seeking Susan as Rosanna Arquette 's sister-in-law.